Pathology | Eastern Health

Test & Collection Guide

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Copeptin

Ordering information:

This test has replaced Anti Diuretic Hormone (ADH)

This test is not Medicare Rebateable.

Test cost: $50

This test must be approved by the Chemical Pathologist before sending.

Sample is sent to Northern Pathology

Laboratory:

Referred Test

Test Code:

COPEP

Specimen types:

Serum

Container types:

Serum tube with gel

Collection Instructions:

Transport specimen at Room Temperature to lab

Samples are to be centrifuged, aliquoted and frozen at -20 degrees within 24 hours of collection.

Samples to be sent frozen.

Minimum Adult Volume:

1 mL

Paediatric Minimum Volume:

1 mL

Frequency:

Mon-Fri

Result Turnaround Time:

2 days

Reference Interval:

For the investigation of diabetes insipidus (DI) and primary polydipsia (PP) in patients with confimed polyuria (>40 mL/kg/d.*

A baseline Copeptin level >21.4 pmol/L is 100% sensitive and specific for nephrogenic diabetes insipidus.

A baseline Copeptin level <2.6 pmol/L with prior fluid deprivation (>8hr) will indicate complete central DI likely

A stimulated Copeptin** >4.9 pmol/L PP likely and <4.9 pmol/L partial central DI likely (94.0% specificity and 94.4% sensitivity)

_{*Without concurrent diabetes mellitus, hypercalcemia, pregnancy, uncorrected thyroid or adrenal insufficieny, and heart failure; **at sodium levels >147mmol/L following water deprivation.}

Laboratory Use Only

Storage Instructions:

Samples are to be centrifuged, aliquoted and frozen at -20 degrees within 24 hours of collection.

Laboratory Notes:

Samples are to be sent to

Northern Pathology Victoria

Northern Health

185 Cooper Street

Epping VIC 3076