Test & Collection Guide

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PLEASE NOTE: Recent changes have been made to this Test

 Recent changes for HMG-CoA Reductase

Recent changes for HMG-CoA Reductase

Changed From
Changed To
7th February 2020
Alternative names

3-Hydroxy-3-Methylglutaryl-coenzyme A Reductase), Anti-HMGCR, Autoantibodies to HMGCR

3-Hydroxy-3-Methylglutaryl-coenzyme A Reductase, Anti-HMGCR, Autoantibodies to HMGCR

HMG-CoA Reductase

Ordering information:

This test is non-MBS rebateable and should be accompanied by a patient consent form.

  HMG-CoA Reductase (3-hydroxy-3-methylglutaryl-coenzyme A Reductase) antibodies are associated with autoimmune (immune-mediated) necrotizing myopathies.

More than 60% of patients with anti-HMG-CoA reductase antibodies have current or previous exposure to statin therapy.

Autoantibody levels to HMG-CoA reductase correlate to clinical findings and CK levels.

The manifestations of anti-HMG-CoA reductase statin-associated immune-mediated necrotizing myopathy mainly affect skeletal muscle.


Alternate names:
3-Hydroxy-3-Methylglutaryl-coenzyme A Reductase, Anti-HMGCR, Autoantibodies to HMGCR
Referred Test
Test Code:
Specimen types:
Container types:
Serum tube with gelSerum tube with gel
Minimum Adult Volume:
2 mL
Paediatric Minimum Volume:
1 mL
As required
Result Turnaround Time:
4-6 weeks
Reference Interval:

Detected/Not Detected

Laboratory Use Only
Storage Instructions:

Spin,separate serum and freeze.

Transport Instructions:

Transport frozen.

External Laboratory:
Sydney South West Pathology Service(RPA)
 External Laboratory details...