Pathology

Test & Collection Guide

HMG-CoA Reductase

Ordering information:

This test is non-MBS rebateable and should be accompanied by a patient consent form.

HMG-CoA Reductase (3-hydroxy-3-methylglutaryl-coenzyme A Reductase) antibodies are associated with autoimmune (immune-mediated) necrotizing myopathies.

More than 60% of patients with anti-HMG-CoA reductase antibodies have current or previous exposure to statin therapy.

Autoantibody levels to HMG-CoA reductase correlate to clinical findings and CK levels.

The manifestations of anti-HMG-CoA reductase statin-associated immune-mediated necrotizing myopathy mainly affect skeletal muscle.

Alternate names:

3-Hydroxy-3-Methylglutaryl-coenzyme A Reductase, Anti-HMGCR, Autoantibodies to HMGCR

Laboratory:

Referred Test

Test Code:

BMISC

Specimen types:

Blood

Container types:

Serum tube with gel

Minimum Adult Volume:

2 mL

Paediatric Minimum Volume:

1 mL

Frequency:

As required

Result Turnaround Time:

4-6 weeks

Reference Interval:

Detected/Not Detected

Laboratory Use Only

Storage Instructions:

Spin,separate serum and freeze.

Transport Instructions:

Transport frozen.

External Laboratory:

Sydney South West Pathology Service(RPA)

External Laboratory details...