Test & Collection Guide

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PLEASE NOTE: Recent changes have been made to this Test

 Recent changes for Imatinib Level

Recent changes for Imatinib Level

Changed From
Changed To
4th April 2019
Request Group


14th February 2019
Processing Instructions

Spin,aliquot plasma and freeze.

External Transport Instructions

Frozen sample to be packed by IATA trained personal.

Imatinib Level

Ordering information:

Collect sample just before next dose (trough sample).

NOTE: date,time and amount of last dose must be provided on the request form for result interpretation.

Alternate names:
Referred Test
Test Code:
Specimen types:
Container types:
Collection Instructions:

Collect sample just before next dose (trough sample).

Minimum Adult Volume:
2 mL
As required
Result Turnaround Time:
4 weeks
Reference Interval:

A recent study demonstrated that trough (sample taken just before the next dose) imatinib plasma concentrations were associated with cytogenetic and molecular response in CML. A patient with trough imatinib plasma concentration >1000 ng/ml is 8 times more likely to experience a therapeutic effect compared with patients who have concentrations below this effect target. Furthermore,GIST patients with a trough imatinib plasma concentration <1100 ug/L had lower rates of clinical benifit and faster time to progression. A target for toxicity has not been defined;however,fluid retension,rash,myalgia and anaemia apper to be common at higher imatinib concentrations.

Suggested target for effect in CML is >1000 ug/L

Suggested target for effect in GIST is >1100 ug/L

Toxicity: monitor patient carefully if trough imatinib plasma concentration exceeds 2000 ug/L

Laboratory Use Only
Storage Instructions:

Spin,aliquot plasma and freeze.

Transport Instructions:

Frozen sample to be packed by IATA trained personal.

External Laboratory:
Sydpath Pathology, St Vincent's Hospital NSW
 External Laboratory details...