Pathology

Test & Collection Guide

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Imatinib Level

Ordering information:

Collect sample just before next dose (trough sample).

NOTE: date,time and amount of last dose must be provided on the request form for result interpretation.

Alternate names:

Glivec

Laboratory:

Referred Test

Test Code:

IMAT

Specimen types:

Plasma

Container types:

EDTA

Collection Instructions:

Collect sample just before next dose (trough sample).

Minimum Adult Volume:

2 mL

Frequency:

As required

Result Turnaround Time:

4 weeks

Reference Interval:

A recent study demonstrated that trough (sample taken just before the next dose) imatinib plasma concentrations were associated with cytogenetic and molecular response in CML. A patient with trough imatinib plasma concentration >1000 ng/ml is 8 times more likely to experience a therapeutic effect compared with patients who have concentrations below this effect target. Furthermore,GIST patients with a trough imatinib plasma concentration <1100 ug/L had lower rates of clinical benifit and faster time to progression. A target for toxicity has not been defined;however,fluid retension,rash,myalgia and anaemia apper to be common at higher imatinib concentrations.

Suggested target for effect in CML is >1000 ug/L

Suggested target for effect in GIST is >1100 ug/L

Toxicity: monitor patient carefully if trough imatinib plasma concentration exceeds 2000 ug/L

Laboratory Use Only

Storage Instructions:

Spin,aliquot plasma and freeze.

Transport Instructions:

Frozen sample to be packed by IATA trained personal.

External Laboratory:

Sydpath Pathology, St Vincent's Hospital NSW

External Laboratory details...