Pathology

Test & Collection Guide

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HLA-B 5701

Alternate names:

Abacavir hypersensitivity, HLA B57

Laboratory:

Referred Test

Test Code:

HLAP

Specimen types:

Blood

Container types:

ACD

Collection Instructions:

Transport specimen at Room Temperature to lab

Minimum Adult Volume:

5 mL

Laboratory Use Only

Storage Instructions:

Test is useful for predicting the likelihood of hypersensitivity reactions to abacavir in HIV infected patients.

Hypersensitivty reactions , which generally occur during the first 6 weeks of treatment, are often nonspecific and include skin rashes, gastrointestinal symptoms and respiratory systems. Fatalities have been reported with abacavir. Prospective testing for the HLA-B-5701 genotype and excluding positive individuals from treatment decreases the incidence of abacavir hypersensitivity.

Positivity for HLA-B 5701 confers high risk. Although the negative predictive value of the test is high, a negative result does not preclude the development of an allergic reponse.

In patients who have been recently transfused, genotyping using DNA obtained from WBC's may not provide useful information - wait 4-6 weeks.

14.4.11 CR

External Laboratory:

V.T.I.S (ARCBS)

External Laboratory details...