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Test is useful for: Indentifying individuals of Asian ancestory who are at risk of developing Stevens-Johnson syndrome and toxic epidermal necrolysis when administered carbamazepine, phenytoin or fosphenytoin.
Studies have demonstrated associations between some HLA genotypes and drug induced adverse skin reactions. The frequency of HLA-B 1502 allele varies throughout Asia - being up to 10-15% Chinese, 2-4% SE Asia, including Indians.
Interpretation: positivity for HLA-B1502 confers increased risk for hypersensitivity to above mentioned drugs.
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