Test & Collection Guide

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HLA-B 1502 Genotype

Alternate names:
Carbamazepine hypersensitivity, Phenytoin hypersensitity
Referred Test
Test Code:
Specimen types:
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Collection Instructions:
Transport specimen at Room Temperature to lab
Minimum Adult Volume:
5 mL
Laboratory Use Only
Laboratory Notes:

Test is useful for: Indentifying individuals of Asian ancestory who are at risk of developing Stevens-Johnson syndrome and toxic epidermal necrolysis when administered carbamazepine, phenytoin or fosphenytoin.

Studies have demonstrated associations between some HLA genotypes and drug induced adverse skin reactions. The frequency of HLA-B 1502 allele varies throughout Asia - being up to 10-15% Chinese, 2-4% SE Asia, including Indians.

Interpretation: positivity for HLA-B1502 confers increased risk for hypersensitivity to above mentioned drugs.

130411 CR

External Laboratory:
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