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Test & Collection Guide

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Dexamethasone Suppression Test

Laboratory:
Unassigned
Specimen types:
Serum
Container types:
Serum tube with gelSerum tube with gel
Collection Instructions:

The Dexamethasone Suppression Test (DST), also referred to as the "low dose DST" or "overnight DST", is a screening test for Cushing's Syndrome.

The requesting clinician should give the patient a 1mg dexamethasone tablet with instructions to take it at 11 pm. (for outpatients: the tablet should only be taken Sunday to Friday evening, to ensure collection next day.)

The patient must present to the collection centre the following morning ( preferably before 10am ) and have a serum sample taken for cortisol analysis.

If there is any doubt do not send the patient away without documented consultation with a senior scientist. ( 9895 3548)

Endocrine consultation is suggested for "High Dose DST".

Dexamethasone levels will not be performed without consultation with Endocrinology and the Chemical Pathologist.

Frequency:
Daily
Result Turnaround Time:
2-4 hours
Reference Interval:

Cortisol < 50 nmol/L is considered normal and NOT consistent with Cushing's Syndrome.

Laboratory Use Only
Storage Instructions:

Endocrine consultation is suggested for "High Dose DST".

Laboratory Notes:

Dexamethasone Level requires 2 mL aliquot of serum or plasma, Transported on Ice, to:

Analytical Chemistry HPLC - Central (RBWH)

Pathology Handbook

Test & Collection Guide

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