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Test & Collection Guide

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Creatine Kinase, MB Fraction

Ordering information:

No clinical use. Only available for CCU clinical trial.

Alternate names:
CKMB
Laboratory:
Referred Test
Specimen types:
Serum
Container types:
Serum tube with gelSerum tube with gel
Notes:

Cardiac Troponin T is a more sensitive and more specific marker of cardiac damage than CKMB. Troponin has largely replaced CKMB

Total CK is always assayed first. CKMB is not generally performed where Total CK is < 200 U/L, and is not indicated where Total CK is > 10,000 U/L

The CKMB (mass) assay is largely free from the non-specific reactions seen in the older enzyme-activity assays

Caution should be exercised in the diagnosis of myocardial damage where the total CK is very high, eg: > 5000 U/L.

Small amounts of CKMB may be found in skeletal muscle

Both percent and absolute levels of CKMB may exceed the quoted values

Only available for CCU clinical trial.

Reference Interval:

Myocardial damage is probable when the following triad exists:

 

CK (Total) > 200 U/L
CKMB-mass > 10 mg/L
MB index > 5
Laboratory Use Only
External Laboratory:
Royal Melbourne Hospital
 External Laboratory details...

Pathology Handbook

Test & Collection Guide

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