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Test & Collection Guide

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Imatinib Level

Ordering information:

Collect sample just before next dose (trough sample).

NOTE: date,time and amount of last dose must be provided on the request form for result interpretation.

Alternate names:
Glivec
Laboratory:
Referred Test
Test Code:
IMAT
Specimen types:
Plasma
Container types:
EDTAEDTA
Collection Instructions:

Collect sample just before next dose (trough sample).

Minimum Adult Volume:
2 mL
Frequency:
As required
Result Turnaround Time:
4 weeks
Reference Interval:

A recent study demonstrated that trough (sample taken just before the next dose) imatinib plasma concentrations were associated with cytogenetic and molecular response in CML. A patient with trough imatinib plasma concentration >1000 ng/ml is 8 times more likely to experience a therapeutic effect compared with patients who have concentrations below this effect target. Furthermore,GIST patients with a trough imatinib plasma concentration <1100 ug/L had lower rates of clinical benifit and faster time to progression. A target for toxicity has not been defined;however,fluid retension,rash,myalgia and anaemia apper to be common at higher imatinib concentrations.

Suggested target for effect in CML is >1000 ug/L

Suggested target for effect in GIST is >1100 ug/L

Toxicity: monitor patient carefully if trough imatinib plasma concentration exceeds 2000 ug/L

Laboratory Use Only

  

 

If EMR is not available, Pathology results are available from Auscare.  If you do not have an Auscare login,please complete attached form. https://pathology.easternhealth.org.au/handbook/downloads/Auscare%20access.pdf

Instruction on how to use Auscare - https://pathology.easternhealth.org.au/handbook/downloads/Auscare%20instructions.pdf

SPECIMEN COLLECTION MODULE (SCM) FAQs - CLICK HERE

CLICK HERE for a consent form to perform tests not covered by Medicare

TURN AROUND TIMES - When will my result be available?

CLICK HERE for Minimum Labelling Requirements

CLICK HERE for a printable Pathology request form

CLICK HERE for a Log sheet for recording Pathology results

"THE ART OF CCCCOLLECTION"

PLEASE CLICK HERE FOR THE PREFERRED ORDER OF DRAW