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Test & Collection Guide

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Imatinib Level

Ordering information:

Collect sample just before next dose (trough sample).

NOTE: date,time and amount of last dose must be provided on the request form for result interpretation.

Alternate names:
Glivec
Laboratory:
Referred Test
Test Code:
IMAT
Specimen types:
Plasma
Container types:
EDTAEDTA
Collection Instructions:

Collect sample just before next dose (trough sample).

Minimum Adult Volume:
2 mL
Frequency:
Twice weekly
Result Turnaround Time:
4 weeks
Reference Interval:

A recent study demonstrated that trough (sample taken just before the next dose) imatinib plasma concentrations were associated with cytogenetic and molecular response in CML. A patient with trough imatinib plasma concentration >1000 ng/ml is 8 times more likely to experience a therapeutic effect compared with patients who have concentrations below this effect target. Furthermore,GIST patients with a trough imatinib plasma concentration <1100 ug/L had lower rates of clinical benifit and faster time to progression. A target for toxicity has not been defined;however,fluid retension,rash,myalgia and anaemia apper to be common at higher imatinib concentrations.

Suggested target for effect in CML is >1000 ug/L

Suggested target for effect in GIST is >1100 ug/L

Toxicity: monitor patient carefully if trough imatinib plasma concentration exceeds 2000 ug/L

Laboratory Use Only

  

Accessing Results

EMR: Pathology results are available via EMR.

Auscare: If EMR is unavailable, results can be accessed through Auscare. Don’t have an Auscare login? Complete the Auscare User Form.

To access Auscare, see instructions.

 

Forms & Collection Guides

Consent Form – Non-Medicare Tests
For tests not covered by Medicare. Download Form  

Pathology Request Form
Printable referral form for submitting pathology requests. Download Form.

Microbiology Swab Collection Guide 
Step-by-step instructions for correct swab collection. Download Guide.

Preferred Order of Draw
Instructions to ensure accurate blood collection and results. View Instructions 

 

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