|
Toxoplasmosis |
Rubella |
CMV |
Herpes simplex |
At risk if: |
Maternal symptoms or IgM positive |
Maternal primary infection or re-infection |
Maternal primary infection (50%)
Maternal reinfection or reactivation (?1%) |
Maternal genital infection in pregnancy (recurrent, acquisition of other type if already infected, initial non-primary, primary) |
Initial tests - maternal serology |
Maternal IgG positive and IgM negative:
No further action required.
Maternal IgM + IgG positive:
Request neonatal testing. |
Maternal rubella IgG/IgM if
(i) contact with rubella
(ii) rubella-like illness |
Maternal IgG &/or IgM positive:
Request neonatal testing |
Clinical assessment, antenatal serology or viral PCR results if available |
Neonatal testing if indicated by maternal results and clinical suspicion |
Serology ? IgG & IgM
PCR ? blood*, CSF |
Serology ? rubella IgM
PCR ? urine, throat swab, tears (conjunctival swab), lens tissue (if available) |
Serology ? CMV IgM
PCR ? blood*, urine, saliva |
PCR ? surface swabs (eye, throat, umbilicus, rectum), urine, blood*, CSF if positive surface swabs or infant with clinical illness |
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